Allicin from Garlic as a Potential Stimulator of Pancreatic Beta Cells for Blood Glucose Regulation in Diabetic Mice

Abstract

Background: One of the most prevalent metabolic & endocrine disorders in the globe is diabetes mellitus (DM). Insulin secretion impairment that would resulted from pancreatic β cells damage, which were believed to be important cells implicated in diabetes mellitus development.
Aim: to examine and clarify the underlying mechanism of allicin's protective actions against pancreatic β cell damage.
Methods: The STZ-induced mice DM model was used to study the pharmacological effects of allicin on T2DM in vivo. The studies include monitoring fasting blood sugar levels, conducting oral glucose tolerance tests, measuring serum insulin concentrations, and tracking body weight.
Results: Allicin appears to significantly reduce blood glucose levels and improves insulin secretion and islet architecture, as well as the weight loss associated with diabetes, thus providing important support for metabolism.
Conclusion: Allicin treatment notably reduced progression of T2DM induced by STZ, indicating that allicin may represent a treatment option for patients suffering from T2DM.

Keywords: Allicin; garlic; insulin secretion; beta cells; blood glucose.