Gadolinium deposition in tissue after multi-variable MRI scans

Abstract

Prof.Farouq Hazaimeh, Dr. Eman Almajali, Dr. Fatima Alrousan, Dr. Ali khreisat, Dr. Ahmad Alajlouni
Corresponding Author: drfarouqalhazaimeh@gmail.com

Abstract
GBCAs are highly safe since they were introduced for clinical use in 1988. However, in 2006, kidney systemic fibrosis (NSF) was reported in patients with end-stage renal failure who were exposed to some GBCAs. In 2014, gadolinium deposition was found to occur in brain tissue in patients exposed to multiple GBCA studies.
This project aims to review currently published studies on the accumulation of gadolinium in tissue after repeated GBCA administrations to identify and summarize the recent results of this problem. Six scientific databases of relevant studies were searched electronically between 2009 and July 2016. References have also been checked and tracked to find relevant articles. Studies have been evaluated as relevant either by scanning their titles and summaries or reading the full text.
Initial research resulted in 1765 papers, which were then narrowed to 14 studies that met the criteria for inclusion. Two other studies were found by manually searching the references lists. Of these studies, three assessed the retention of gadolinium in brain tissue on animal models, while the remaining 13 were human research studies.
Keywords: Gadolium Deposition, Multiple MRI imaging, Enriched Nos.