Flow Cytometry Confirmation Post Newborn Screening for SCID in England

Abstract

by Kimberly C. Gilmour
Int. J. Neonatal Screen. 2022, 8(1), 1; https://doi.org/10.3390/ijns8010001 - 2022
Cited by 2 | Viewed by 2825
Abstract
An evaluation program for newborn screening for Severe Combined Immunodeficiency began in England in September 2021 based on TREC analysis. Flow cytometry is being used as the follow up diagnostic test for patients with low/absent TRECS. The immunology laboratories have established a protocol and values for diagnosing SCID, other T lymphopenias and identifying healthy babies. This commentary describes the flow cytometry approach used in England to define SCID, T lymphopenia and normal infants after a low TREC result. It provides background to the flow cytometry assays being used and discusses the need to monitor and potentially change these values over time. Full article
(This article belongs to the Special Issue Newborn Screening for Severe Combined Immune Deficiency—Selected Papers from the ISNS-SCID Meeting)
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